Cyclopentanecarboxylic acid, 2-oxo-, methyl ester → HCID 21527662, compound

HRID 1658505Notes

Reaction equation

HRID 1658505 reaction equation
[NH2:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[CH:5]=[CH:4][N:3]=1.C[O:11][C:12]([CH:14]1[C:18](=O)[CH2:17][CH2:16][CH2:15]1)=O>COCCO>[CH3:8][C:7]1[C:2]2=[N:1][C:15]3[CH2:16][CH2:17][CH2:18][C:14]=3[C:12](=[O:11])[N:3]2[CH:4]=[CH:5][C:6]=1[CH3:9]

Participants

4

Reactant 2

HCID 66328Cyclopentanecarboxylic acid, 2-oxo-, methyl esterHCID 110078842-Amino-3,4-dimethylpyridine

Product 1

HCID 21527662HCID 21527662, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A solution of 24.4 g. of 2-amino-3,4-dimethylpyridine, 62.4 g. of methyl cyclopentanone-2-carboxylate and 250 ml of ethylene glycol monomethyl ether is stirred and heated under reflux for 40 hours. Workup as in Example 3 gives 28.3 g. of the named product as colorless plates after recrystallization from cyclohexane.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 40 hours
  3. customWorkup as in Example 3 gives 28.3 g
  4. customof the named product as colorless plates after recrystallization from cyclohexane

Sources & evidence

ORD record
ord-d0fe8e6fc59c4d14a72dbefaaf56c85f
Source dataset
uspto-grants-1976_06
Patent number
US03965100

Reaction notes

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