Benzyl Bromide → HCID 12354099, compound

Participants

Reaction Steps

To a solution of 6.1 g. of 2,3-dihydro-5-hydroxycyclopenta[d]pyrido[1,2-a]pyrimidin-10(1H)-one in 100 ml of N,N-dimethylformamide is added, portionwise, a total of 1.6 g of a 50% dispersion of sodium hydride in mineral oil. A yellow precipitate of the sodium salt separates. The mixture is allowed to stir for 0.5 hour at room temperature, and then 6.2 g. of benzyl bromide dissolved in 25 ml of N,N-dimethylformamide is added, dropwise, followed by 100 mg. of copper bronze powder. The mixture is stirred and heated to 100°-110° and kept at that temperature for 2 hours. The hot solution is filtered, concentrated in vacuo, and the solid residue recrystallized from cyclohexane to give 7.2 g. of product, m.p. 150°-152°.

Provenance & Evidence