HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-[3-(p-Fluorophenoxy)-propyl]-4-(p-chlorophenyl)-4-hydroxypiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-(4-Chlorophenyl)-4-hydroxypiperidine | HCID 38282 | — |
| Reactant | 1-(3-Chloropropoxy)-4-fluorobenzene | HCID 74391 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[3-(p-Fluorophenoxy)-propyl]-4-(p-chlorophenyl)-4-hydroxypiperidine | HCID 21527771 | — |
Reaction Steps
A mixture of 2.83 g of 1-chloro-3-(p-fluorophenoxy)-propane, 3.18 g of 4-(p-chlorophenyl)-4-hydroxypiperidine, 0.8 g of sodium carbonate and 60 ml of dimethylformamide is heated at a temperature of 80° - 90°C for 10 hours. After cooling, the reaction mixture is poured into water. The precipitate is collected by filtration and dried to give 1-[3-(p-fluorophenoxy)-propyl]-4-(p-chlorophenyl)-4-hydroxypiperidine, M.P. 134 - 135°C. Recrystallization from benzene gives the purified product, M.P. 136° - 137°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03965106 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-3ac06d4e711343d0a7a941858b0ae3bf |
| Source note | uspto-grants-1976_06 |