Methyl Isocyanate → HCID 21527845, compound

HRID 1658535Notes

Reaction equation

HRID 1658535 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2=[N:15][N:16]([CH2:18][CH3:19])[CH2:17][N:13]2[C:12]2[S:20](=[O:23])[CH2:21][CH2:22][C:11]=2[CH2:10][N:9]=1.[CH3:24][N:25]=[C:26]=[O:27]>C(Cl)(Cl)Cl>[CH3:24][NH:25][C:26]([CH:21]1[S:20](=[O:23])[C:12]2[N:13]3[CH2:17][N:16]([CH2:18][CH3:19])[N:15]=[C:14]3[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])=[N:9][CH2:10][C:11]=2[CH2:22]1)=[O:27]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 21527857HCID 21527857, compound

Product 1

HCID 21527845HCID 21527845, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

9 g of 6-o-chlorophenyl-8-ethyl-1,2-dihydro-4H-s-triazolo [3,4-c]-thieno[2,3-e][1,4]diazepin-1-one is dissolved in 50 ml of chloroform, and 5 ml of methyl isocyanate is added, and the resulting mixture is refluxed for 8 hours. Then the chloroform is removed under reduced pressure, and the remaining jelly-like substance is treated with ligroin to give the title compound as white crystals. The product, when recrystallized from a mixture of ethanol and chloroform, shows a melting point of 193°-194° C.

Workup

  1. temperaturethe resulting mixture is refluxed for 8 hours
  2. customThen the chloroform is removed under reduced pressure
  3. additionthe remaining jelly-like substance is treated with ligroin

Sources & evidence

ORD record
ord-3deea47c07804705af7de5192f4a7526
Source dataset
uspto-grants-1976_06
Patent number
US03965111

Reaction notes

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