Water → HCID 54514258, compound

Participants

Reaction Steps

A solution of N-(2,5-dimethoxybenzyloxy-carbonyl)-para-aminobenzoic acid (3.31g) in dry THF (30ml) was treated with oxalyl chloride (1.65g) and one drop of dry DMF. After 0.5 hour the reaction had subsided and the acid chloride solution was added dropwise to a stirred solution of ethoxyethanol (1.2g) in dry pyridine, then poured into water (ca 250ml) and the crude product extracted into ether. The ether was washed with 1N HCl 1N NaOH, water and dried with Mg SO4. The solvent was concentrated in vacuo leaving a yellow oil.

Provenance & Evidence