Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | P-Cresol | HCID 2879 | — |
| Reactant | 2-Chlorophenol | HCID 7245 | — |
| Reactant | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| Reactant | 4'-Hydroxyacetophenone | HCID 7469 | — |
| Reactant | 4-Bromophenol | HCID 7808 | — |
| Reactant | 3-Chlorophenol | HCID 7933 | — |
| Reactant | 4-Methoxyphenol | HCID 9015 | — |
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | 3-Fluorophenol | HCID 9743 | — |
| Reactant | 4-Cyanophenol | HCID 13019 | — |
| Reactant | Methyl [[(methoxycarbonyl)amino](methylthio)methylene]carbamate | HCID 98708 | — |
| Reactant | HCID 54189253 | HCID 54189253 | — |
| Reactant | HCID 56625616 | HCID 56625616 | — |
| Reactant | HCID 57213372 | HCID 57213372 | — |
| Product | Benzimidazole | HCID 5798 | — |
Reaction Steps
In a similar manner, using phenol, p-cresol, o-chlorophenol, m-chlorophenol, o,p-dichlorophenol, m,p-dichlorophenol, m-trifluoromethylphenol, p-bromophenol, p-fluorophenol, m-fluorophenol, p-acetylphenol, p-cyanophenol, m-hydroxyphenol, and p-methoxyphenol in place of p-chlorophenol, the corresponding 1,2-diamino-4-phenoxy (or substituted phenoxy) benzenes and 2-carbomethoxyamino-5(6)-phenoxy (or substituted phenoxy) benzimidazole compounds are prepared. Using the 1,2-diamino compounds prepared above in this Example, and substituting 1,3-bis-ethoxycarbonyl-S-methyl isothiourea, 1,3-bis-propoxycarbonyl-S-methyl isothiourea, or 1,3-bis-butoxycarbonyl-S-methyl isothiourea for the 1,3-bis-methoxycarbonyl-S-methyl isothiourea, the corresponding 2-carbalkoxyamino-5(6)-phenoxy (or p-substituted phenoxy) benzimidazole compounds are prepared, where R is ethyl, propyl or butyl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03965113 |
|---|
| Source dataset | uspto-grants-1976_06 |
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| ORD ID | ord-17e71ba7e94f448c86aa9a6c2518fe73 |
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| Source note | uspto-grants-1976_06 |
|---|
