Water → HCID 22791110, compound

Participants

Reaction Conditions

Reaction Steps

A solution of concentrated ammonium hydroxide (52 ml., 0.78 mole) and 20 ml. water is added in 10 minutes to a stirred mixture of N-acetyl-L-cysteine (114.2 g., 0.7 mole) in 1.2 liters of isopropanol under an atmosphere of nitrogen. During the addition the mixture thickens and the temperature increases to 35°C. The mixture is stirred overnight, collected and washed with isopropanol to yield 110 g. (87%) of product having a melting point of 156°-158°C. (dec.) (uncorr.). Crystallization of this product from water-isopropanol with cooling to -10°C. provides analytically pure N-acetyl-L-cysteine ammonium salt, M.P. 147.5°-150°C. (dec.) (corr.); [ α ]D25 + 20.6°(c 5,H2O).

Provenance & Evidence