Methanol → Benzoic acid, 5-chloro-2-hydroxy-, methyl ester

Participants

Reaction Steps

5-Chlorosalicylic acid (5 kg.) dissolved in methanol (50 l.) and concentrated sulfuric acid (2 l.), was heated under reflux for 24 hours. The product crystallized when the solution was cooled in a dry ice/acetone mixture, and the solid when collected gave the ester (5 kg., 92%) sufficiently pure to use in the next step. Recrystallization give pure ester m.p. 45°-47°.

Provenance & Evidence