HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 5-Chloro-2-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Chloro-o-anisic acid | HCID 76970 | — |
| Product | 5-Chloro-2-methoxybenzoyl chloride | HCID 12384176 | 72% |
Reaction Steps
5-Chloro-2-methoxybenzoic acid (19 g.) was heated in thionyl chloride 64 ml.) under reflux for 1 hour. Benzene (100 ml.) was then added, and evaporated off under reduced pressure. The solid residue was recrystallized from hexane to give the required product (15 g., 72%) m.p. 59°-60°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03965173 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-c7bbed8cd586406987877510a64cbe53 |
| Source note | uspto-grants-1976_06 |