Sodium Cyanide → HCID 86733505, compound

HRID 1658622Notes

Reaction equation

[Na:1].[C:2]([C:5]1([O:11][CH2:10]1)[CH2:6][C:7]([O-:9])=[O:8])(=[O:4])[NH2:3].[C-:12]#[N:13].[Na+]>>[Na:1].[C:2]([C:5]([OH:11])([CH2:10][C:12]#[N:13])[CH2:6][C:7]([O-:9])=[O:8])(=[O:4])[NH2:3]

Participants

Reactant 2

HCID 8929Sodium Cyanide

HCID 86733506HCID 86733506, compound2×

Product 1

HCID 86733505HCID 86733505, compound

Procedure

To this solution of sodium-3-carbamoyl-3,4-epoxybutyrate was added a 5 molal aqueous solution of NaCN in proportions of 3 mols per mol of sodium-3-carbamoyl-3,4-epoxybutyrate. The system was agitated for about 4 hours at 35°-40°C. The yield to sodium-3-carbamoyl-3-hydroxy-4-cyanobutyrate was virtually quantitative as determined by NMR.

Sources & evidence

ORD record: ord-99538b3bd0b64437a57d25fb3c1c2d06
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03965168

Reaction notes

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