1-(2-Hydroxyethyl)piperazine → HCID 21528501, compound

HRID 1658644Notes

Reaction equation

HRID 1658644 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.CS([CH2:14][C:15]#[C:16][CH:17]1[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[CH:21]=[CH:20][C:19]2[CH:28]=[CH:29][CH:30]=[CH:31][C:18]1=2)(=O)=O>ClCCl>[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:14][C:15]#[C:16][CH:17]2[C:18]3[CH:31]=[CH:30][CH:29]=[CH:28][C:19]=3[CH:20]=[CH:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]2=3)[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 21528388HCID 21528388, compound

Product 1

HCID 21528501HCID 21528501, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This preparation illustrates methods of preparing cyclic amine derivatives of formula A. In this preparation 1 gram of N-β-hydroxyethyl-piperazine is added to a solution containing 0.31 g. of 5-(3-methanesulfonylprop-1-ynyl)-5H-dibenzo[a,d]cycloheptene, according to Example 3, in 20 ml. of dichloromethane at 0°C. The resulting mixture is monitored by thin-layer chromatographic analysis and allowed to stand at room temperature until conversion of the sulfonate ester is essentially complete. The mixture is then worked up and purified according to the procedure described in Example 4, yielding 5-[3-(N'-β-hydroxyethyl-1-piperazinyl)prop-1-ynyl]-5H-dibenzo[a,d]cycloheptene.

Workup

  1. additionis added to a solution
  2. additioncontaining 0.31 g
  3. customat 0°C
  4. custompurified

Sources & evidence

ORD record
ord-5b412d420d99443683dd69fec94ef25d
Source dataset
uspto-grants-1976_06
Patent number
US03965181

Reaction notes

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