HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 68131661, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4'-Fluoroacetophenone | HCID 9828 | — |
| Reactant | 4-Piperidinemethanol, alpha,alpha-diphenyl-, hydrochloride (1:1) | HCID 15722 | — |
| Catalyst | Isopropanol | HCID 3776 | — |
| Product | HCID 68131661 | HCID 68131661 | — |
Reaction Steps
A mixture of 30.4 g (0.1 mole) of α,α -diphenyl-4-piperidinemethanol hydrochloride, 9 g (0.3 mole) of paraformaldehyde and 13.8 g (0.1 mole) of 4' -fluoroacetophenone in 100 ml of isopropyl alcohol containing 2 drops of concentrated HCl was refluxed for 24 hours. The mixture was filtered and the filtrate concentrated to about 100 ml and cooled. The resulting precipitate was filtered off and recrystallized from ethanol and isopropyl alcohol to give the desired product, M.P. 250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03965257 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-00d0a11516944b14ba59952125e8865f |
| Source note | uspto-grants-1976_06 |