Hydrochloric Acid → HCID 20380010, compound

Participants

Reaction Steps

To 53.4 g (0.2 mole) of α,α -diphenyl-4-piperidinemethanol in 1 liter of toluene was added 38.4 g (0.21 mole) of 4-chlorobutyrophenone, 21 g (0.25 mole) of sodium bicarbonate and 0.1 g of potassium iodide. The mixture was stirred and refluxed for 72 hours then filtered. The filtrate was concentrated to 300 ml and allowed to stand at room temperature until a precipitate formed. The precipitate was filtered off and dissolved in hot toluene, filtered and cooled. A solid formed which was dissolved in diethyl ether and treated with ethereal HCl. The resulting product was recrystallized from methanolbutanone to give the title compound, M.P. 193.5°-195° C.

Provenance & Evidence