Azacyclonol → HCID 21528594, compound

Participants

Reaction Steps

To 40 g (0.15 mole) of α,α -diphenyl-4-piperidine-methanol in 800 ml of benzene was added 16.8 g (0.2 mole) of sodium bicarbonate followed by 27.6 g (0.16 mole) of 2-chloro-4'-fluoroacetophenone in 25 ml of benzene. The mixture was stirred and refluxed for 53 hours, filtered, and the filtrate was concentrated to an oil. The oil was dissolved in diethyl ether, washed with water, dried over anhydrous magnesium sulfate, filtered and treated with ethereal HCl. The resulting precipitate was recrystallized from ethanol-water and ethanol-hexane to give the title compound, M.P. 171°-174°C, (anhydrous 231°-3°C).

Provenance & Evidence