Potassium Iodide → HCID 21528589, compound

Participants

Reaction Steps

A mixture of 15 g (0.035 mole) of 4'-fluoro-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone, the free base of the compound of Example 1, and a small amount of potassium iodide in 100 ml of piperidine was refluxed for 22 hours. The unreacted piperidine was removed under vacuum, and the remaining residue was triturated with water, the water decanted, and the residue dissolved in methanol and added to a large amount of water. The resulting precipitate was dissolved in a large volume of ether, dried over magnesium sulfate, treated with charcoal and filtered. The filtrate was concentrated to a 50 ml volume and cooled, yielding a product which was recrystallized from ether to give the title compound, M.P. 137.5°-139° C.

Provenance & Evidence