Potassium Iodide → HCID 21528617, compound

Participants

Reaction Steps

A mixture of 175.5 g (0.7 mole) of 4-diphenylmethylpiperidine, 63.6 g (0.35 mole) of 4-chlorobutyrophenone, 600 ml of toluene, and a small amount of potassium iodide was refluxed for three days then allowed to stand at room temperature one day. The solvent was removed at reduced pressure, and one liter of dry ether was added after which the mixture was filtered. The filtrate was concentrated, and the residue was dissolved in 75°-90° petroleum ether treated with charcoal and filtered. The filtrate was cooled to room temperature and the resulting precipitate was filtered off, and dissolved in ether then treated with ethereal HCl. A precipitate formed which was recrystallized from methanol-butanone to give the desired product, M.P. 163.5°-164.5° C.

Provenance & Evidence