HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1658690Generated: October 26, 2026
Formaldehyde → N-(Hydroxymethyl)-2-(thiophen-2-yl)acetamide
https://huagongshe.com/reaction/1658690
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Thiophen-2-acetamide | HCID 78208 | — |
| Product | N-(Hydroxymethyl)-2-(thiophen-2-yl)acetamide | HCID 21452354 | — |
Reaction Steps
A mixture of 2-thienylacetamide, formaldehyde solution (37%, 1 equivalent) and a catalytic amount of potassium carbonate is warmed on a steam bath until a homogeneous solution is obtained. The solution is cooled to 0° C. overnight and the resulting solid collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03966710 |
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| Source dataset | uspto-grants-1976_06 |
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| ORD ID | ord-8c4868c90c71407c9c7cef1a16ef409c |
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| Source note | uspto-grants-1976_06 |
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