Triphenylstannane → HCID 13990933, compound

Participants

Reaction Steps

1.2 g. of 9-chloro-11β-fluoro-4-androstene-3,17-dione is agitated for 2 hours at room temperature in 20 ml. of tetrahydrofuran and 3 ml. of triphenyltin hydride with the addition of 7 mg. of α,α'-azoisobutyrodinitrile. The solution is evaporated under vacuum and worked up as set forth in Example 1. After purification by preparative layer chromatography, 380 mg. of 11β-fluoro-4-androstene-3,17-dione is obtained; m.p. 162°-164°. UV: ε238 = 16,300 (methanol).

Provenance & Evidence