Triphenylstannane → HCID 68147036, compound

Participants

Reaction Steps

230 mg. of 17β-acetoxy-9-bromo-11β-fluoro-1,4,6-androstatrien-3-one is stirred at room temperature for 5 hours in 7 ml. of tetrahydrofuran with 1 ml. of triphenyltin hydride while adding 1 mg. of α,α'-azoisobutyrodinitrile. The solution is worked up as disclosed in Example 1. After purification by preparative layer chromatography, 70 mg. of 17β-acetoxy-11β-fluoro-1,4,6-androstatrien-3-one is isolated. UV: ε298 = 11,800 (methanol).

Provenance & Evidence