Trifluoroacetic acid → HCID 131710347, compound

Participants

Reaction Steps

4-t-Butoxycarbonyl-7-carboxymethylthioacetamido-3-(3-pyridylmethyl)ceph-3-em (XLIV) (250 mg.) was dissolved in trifluoroacetic acid (3 ml.) and allowed to stand at room temperature for 15 mins. The trifluoroacetic acid was stripped off under reduced pressure and the last traces removed by additions of dry toluene and reevaporation. The residue was taken up in acetone (1 ml.) and the small amount of insoluble material discarded. The title compound (XLV) ws precipitated by careful addition of the acetone solution to dry ether (10 ml.). It was an off-white non-crystalline powder (150 mg., 54%);

Provenance & Evidence