Potassium Carbonate → HCID 21525488, compound

Participants

Reaction Steps

A mixture of 25.0 grams of 1-[2-(4-methyl-2-methoxyphenoxy)ethyl]piperazine, 20.1 grams of 3-(4-fluorobenzoyl)propyl chloride, 13.8 grams of potassium carbonate and 10 grams of potassium bromide was heated under gentle reflux for a period of 24 hours. The resulting reaction mixture was filtered while hot and the filtrate after cooling was acidified by adding thereto with stirring a 10% solution of hydrochloric acid, whereupon the compound that is specified in the heading separated. The resulting precipitate was then separated by filtration and recrystallized from a mixture of 80 parts by volume of ethanol and 20 parts by volume of water. In this manner, 15 grams of the salt specified in the heading, having a melting point of 211°-213°C, was obtained.

Provenance & Evidence