Butylamine → 4-butylamino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

HRID 1658762Notes

Reaction equation

HRID 1658762 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](OCC)=[C:8]2[CH:14]=[N:13][NH:12][C:9]2=[N:10][CH:11]=1)=[O:5])[CH3:2].[CH2:18]([NH2:22])[CH2:19][CH2:20][CH3:21]>O>[CH2:1]([O:3][C:4]([C:6]1[C:7]([NH:22][CH2:18][CH2:19][CH2:20][CH3:21])=[C:8]2[CH:14]=[N:13][NH:12][C:9]2=[N:10][CH:11]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 14590535CID 14590535

Product 1

HCID 537827204-butylamino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-Ethoxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester is treated with butylamine at 90° for 1 hour. After this period the mixture is cooled, diluted with water and the white crystalline precipitate is filtered off. Recrystallization from diethyl ether yields 4-butylamino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester.

Workup

  1. temperatureAfter this period the mixture is cooled
  2. filtrationthe white crystalline precipitate is filtered off
  3. customRecrystallization from diethyl ether

Sources & evidence

ORD record
ord-c1983b9bcc64410aa3313d53bd41fb6a
Source dataset
uspto-grants-1976_06
Patent number
US03966746

Reaction notes

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