Phosphorus sulfide (P2S5) → HCID 21525556, compound

HRID 1658771Notes

Reaction equation

HRID 1658771 reaction equation
[Cl:1][C:2]1[C:3]([Cl:28])=[CH:4][C:5]2[N:11]([C:12](=[O:21])[CH2:13][N:14]([CH2:18][CH2:19][CH3:20])[CH2:15][CH2:16][CH3:17])[C:10]3[N:22]=[CH:23][CH:24]=[CH:25][C:9]=3[C:8](=O)[NH:7][C:6]=2[CH:27]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:30]>N1C=CC=CC=1>[Cl:1][C:2]1[C:3]([Cl:28])=[CH:4][C:5]2[N:11]([C:12](=[O:21])[CH2:13][N:14]([CH2:18][CH2:19][CH3:20])[CH2:15][CH2:16][CH3:17])[C:10]3[N:22]=[CH:23][CH:24]=[CH:25][C:9]=3[C:8](=[S:30])[NH:7][C:6]=2[CH:27]=1

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 21525525HCID 21525525, compound

Product 1

HCID 21525556HCID 21525556, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In the manner given in Example 1, 8,9-dichloro-6,11-dihydro-11-[(dipropylamino)acetyl]-5H-pyrido[2,3-b][1,5]-benzodiazepin-5-one is reacted with phosphorus pentasulfide in pyridine to give 8,9-dichloro-6,11-dihydro-11-[(dipropylamino)acetyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-thione.

Sources & evidence

ORD record
ord-326c1b5688514783b9a23b2bad22499e
Source dataset
uspto-grants-1976_06
Patent number
US03966736

Reaction notes

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