Phosphorus sulfide (P2S5) → HCID 21525580, compound

HRID 1658773Notes

Reaction equation

HRID 1658773 reaction equation
[Br:1][C:2]1[C:3]([Br:30])=[CH:4][C:5]2[N:11]([C:12](=[O:23])[CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][OH:22])[CH2:16][CH2:15]3)[C:10]3[N:24]=[CH:25][CH:26]=[CH:27][C:9]=3[C:8](=O)[NH:7][C:6]=2[CH:29]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:32]>N1C=CC=CC=1>[Br:1][C:2]1[C:3]([Br:30])=[CH:4][C:5]2[N:11]([C:12](=[O:23])[CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][OH:22])[CH2:16][CH2:15]3)[C:10]3[N:24]=[CH:25][CH:26]=[CH:27][C:9]=3[C:8](=[S:32])[NH:7][C:6]=2[CH:29]=1

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 21525528HCID 21525528, compound

Product 1

HCID 21525580HCID 21525580, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In the manner given in Example 1, 8,9-dibromo-6,11-dihydro-11-[[4-(2-hydroxyethyl)piperazino]acetyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one is reacted with phosphorus pentasulfide in pyridine to give 8,9-dibromo-6,11-dihydro-11-[[4-(2-hydroxyethyl)piperazino]acetyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-thione.

Sources & evidence

ORD record
ord-643047ce18094240a27754226a8aa836
Source dataset
uspto-grants-1976_06
Patent number
US03966736

Reaction notes

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