Hydrazinecarboxylic acid, ethyl ester → HCID 21525505, compound

HRID 1658783Notes

Reaction equation

HRID 1658783 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][C:11]([N:13]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[NH:17][C:16](=S)[C:15]3[CH:25]=[CH:26][CH:27]=[N:28][C:14]2=3)=[O:12])[CH2:6][CH2:5]1.[C:29](OCC)(=[O:32])[NH:30][NH2:31]>>[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][C:11]([N:13]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[N:17]3[C:29](=[O:32])[NH:30][N:31]=[C:16]3[C:15]3[CH:25]=[CH:26][CH:27]=[N:28][C:14]2=3)=[O:12])[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 21525511HCID 21525511, compound

Product 1

HCID 21525505HCID 21525505, compound

Procedure

In the manner given in Example 13, 6,11-dihydro-11-[[4-(2-hydroxyethyl)piperazino]acetyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-thione is heated to about 200° C. with ethyl carbazate to give 2,9-dihydro-9-[[4-(2-hydroxyethyl)-piperazino]acetyl]-3H-pyrido[3,2-c]-s-triazolo[4,3-a][1,5]benzodiazepin-3-one.

Sources & evidence

ORD record
ord-fa84c8f186e741c7bb7c21c863e720b6
Source dataset
uspto-grants-1976_06
Patent number
US03966736

Reaction notes

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