Hydrazinecarboxylic acid, ethyl ester → HCID 21525521, compound

HRID 1658787Notes

Reaction equation

HRID 1658787 reaction equation
[CH3:1][C:2]1[C:3]([CH3:30])=[CH:4][C:5]2[N:11]([C:12](=[O:23])[CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][OH:22])[CH2:16][CH2:15]3)[C:10]3[N:24]=[CH:25][CH:26]=[CH:27][C:9]=3[C:8](=S)[NH:7][C:6]=2[CH:29]=1.[C:31](OCC)(=[O:34])[NH:32][NH2:33]>>[CH3:1][C:2]1[C:3]([CH3:30])=[CH:4][C:5]2[N:11]([C:12](=[O:23])[CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][OH:22])[CH2:16][CH2:15]3)[C:10]3[N:24]=[CH:25][CH:26]=[CH:27][C:9]=3[C:8]3[N:7]([C:31](=[O:34])[NH:32][N:33]=3)[C:6]=2[CH:29]=1

Participants

3

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 21525593HCID 21525593, compound

Product 1

HCID 21525521HCID 21525521, compound

Procedure

In the manner given in Example 11, 8,9-dimethyl-6,11-dihydro-11-[[4-(2-hydroxyethyl)piperazino]acetyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-thione is heated to about 200° C. with ethyl carbazate to give 6,7-dimethyl-2,9-dihydro-9-[[4-(2-hydroxyethyl)piperazino]acetyl]-3H-pyrido[3,2-c]-s-triazolo[4,3-a][1,5]benzodiazepin- 3-one.

Sources & evidence

ORD record
ord-164e9fb140114c43a6408dbef76161e1
Source dataset
uspto-grants-1976_06
Patent number
US03966736

Reaction notes

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