Sodium borohydride → HCID 21505620, compound

HRID 1658804Notes

Reaction equation

HRID 1658804 reaction equation
Cl([O-])(=O)(=O)=O.[F:6][C:7]1[CH:32]=[CH:31][C:10]([C:11]([CH2:13][CH2:14][CH2:15][N+:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[O:24][N:23]=3)=[CH:18][CH:17]=2)=[O:12])=[CH:9][CH:8]=1.[BH4-].[Na+]>CO>[F:6][C:7]1[CH:32]=[CH:31][C:10]([CH:11]([OH:12])[CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH:18]=[C:19]([C:22]3[CH:26]=[C:25]([C:27]([F:29])([F:30])[F:28])[O:24][N:23]=3)[CH2:20][CH2:21]2)=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86733607HCID 86733607, compound

Product 1

HCID 21505620HCID 21505620, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a 1.0 g. portion of 1-(3-p-fluorobenzoylpropyl)-4-[5-(trifluoromethyl)-3-isoxazolyl]pyridinium perchlorate, prepared as described in Example 8, in 40 ml. of methanol, is added portionwise with stirring 1.0 g. of sodium borohydride. The mixture is stirred for 2 hours and poured into ice-water causing the formation of a white solid which is collected and recrystallized from methanol, m.p. 120.5°-121.5°C.

Workup

  1. stirringThe mixture is stirred for 2 hours
  2. customis collected
  3. customrecrystallized from methanol, m.p. 120.5°-121.5°C.

Sources & evidence

ORD record
ord-b9b9f33482e44efcbec78405da0e4fc1
Source dataset
uspto-grants-1976_06
Patent number
US03966748

Reaction notes

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