HCID 21505599, compound → HCID 21525672, compound

HRID 1658807Notes

Reaction equation

HRID 1658807 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:23])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH:16]=[C:15]([C:18]3[O:19][CH:20]=[CH:21][N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:23])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[O:19][CH:20]=[CH:21][N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 21505599HCID 21505599, compound

Product 1

HCID 21525672HCID 21525672, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A 0.32 g. portion of 3,6-dihydro-α-(p-fluorophenyl)-4-(2-oxazolyl)-1(2H)-pyridinebutanol, prepared as described in Example 15, is dissolved in 10 ml. of ethanol and 0.1 g. of palladium on carbon catalyst is added. The mixture is reduced at room temperature and pressure for 4 hours and then filtered. The filtrate is evaporated giving an oil which solidifies to a white solid. This solid is recrystallized twice from acetonitrile, m.p. 99°-100°C.

Workup

  1. dissolutionis dissolved in 10 ml
  2. customis reduced at room temperature
  3. filtrationfiltered
  4. customThe filtrate is evaporated
  5. customgiving an oil which
  6. customThis solid is recrystallized twice from acetonitrile, m.p. 99°-100°C.

Sources & evidence

ORD record
ord-de1a2b649bd7474c912c0e76e4af0c36
Source dataset
uspto-grants-1976_06
Patent number
US03966748

Reaction notes

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