Sodium Hydroxide → HCID 53951827, compound

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Reaction Steps

22.8 g. of 2,7,11-trimethyl-2,4,10-dodecatrienoic acid methyl ester is dissolved in 150 ml of methanol and mixed with 22.8 g. of sodium hydroxide dissolved in 35 ml of water. The mixture is boiled under reflux for 3 hours, poured on to ice-water and extracted with diethyl ether. The ether extracts are discarded and the aqueous phase acidified with dilute sulphuric acid. The acidic aqueous solution is extracted with diethyl ether and the ether extract is washed repeatedly with aqueous sodium chloride solution, dried over sodium sulphate, filtered and concentrated on a rotary evaporator. There is obtained 2,7,11-trimethyl-2,4,10-dodecatrienoic acid.

Provenance & Evidence