Monobasic potassium phosphate → Nordiazepam

Participants

Reaction Steps

2.1 g. (0.005 mole) of 4306 CB and 0.68 g. (0.005 mole) of monopotassium phosphate are dissolved at room temperature in 18 ml. of water. Solution proceeds rapidly and then colorless platelets slowly precipitate. The product is filtered by suction, washed first with chilled water and then with absolute alcohol. The product is dried at room temperature for 12 hours and then in a high vacuum. 1.8 g. of colorless crystals completely soluble in water are obtained. The aqueous solution has a substantially neutral reaction; yield 80%. This product is decarboxylated within a few minutes by heating an aqueous solution thereof, compound A being obtained in the crystalline state.

Provenance & Evidence