Sodium Hydroxide → Amphetamine

HRID 1658939Notes

Reaction equation

HRID 1658939 reaction equation
S(O)(O)(=O)=O.[NH2:6][CH:7]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:8].[OH-].[Na+]>ClCCl>[NH2:6][CH:7]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 222898Amphedrine

Product 1

HCID 3007AmphetamineYield 126.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Amphetamine sulfate (2.76 g) was treated with 2N-sodium hydroxide solution and dichloromethane to give free amphetamine (2.03 g)

Sources & evidence

ORD record
ord-85a1c0383acf4356b98e781db62525f9
Source dataset
uspto-grants-1976_06
Patent number
US03966764

Reaction notes

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