Chloroacetaldehyde → HCID 21412830, compound

HRID 1658965Notes

Reaction equation

HRID 1658965 reaction equation
[CH2:1]([C:4]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:5]=1[NH2:6])[CH2:2][CH3:3].Cl[CH2:13][CH:14]=[O:15].C(=O)([O-])[O-].[Na+].[Na+]>>[CH2:1]([C:4]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:5]=1[NH:6][CH2:13][CH:14]=[O:15])[CH2:2][CH3:3]

Participants

4

Reactant 3

HCID 33ChloroacetaldehydeHCID 10340Sodium CarbonateHCID 214128445-Fluoro-2-propylaniline

Product 1

HCID 21412830HCID 21412830, compound

Conditions

Temperature
150 °C

Procedure

2-Propyl-5-fluoroaniline (0.3 mole), the dimethyl acetal of 2-chloroacetaldehyde (0.3 mole) and sodium carbonate (20 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at about 150°C for a period of about 8 hours. After this time the mixture is filtered and the filtrate is distilled to yield the desired product the dimethyl acetal of 2-(2-propyl-5-fluoroanilino)acetaldehyde.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. filtrationAfter this time the mixture is filtered
  4. distillationthe filtrate is distilled

Sources & evidence

ORD record
ord-dd0f74256beb4ac3b41e9b45a72b86df
Source dataset
uspto-grants-1976_06
Patent number
US03966811

Reaction notes

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