Chloroacetaldehyde → HCID 21412840, compound

HRID 1658974Notes

Reaction equation

HRID 1658974 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([CH2:9][O:10][CH3:11])=[CH:5][C:3]=1[NH2:4].Cl[CH2:13][CH:14]=[O:15].C(=O)([O-])[O-].[Na+].[Na+]>>[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([CH2:9][O:10][CH3:11])=[CH:5][C:3]=1[NH:4][CH2:13][CH:14]=[O:15]

Participants

4

Reactant 3

HCID 33ChloroacetaldehydeHCID 10340Sodium CarbonateHCID 21412843HCID 21412843, compound

Product 1

HCID 21412840HCID 21412840, compound

Conditions

Temperature
150 °C

Procedure

2-Methyl-5-methoxymethylaniline )0.3 mole), the dimethyl acetal of 2-chloroacetaldehyde (0.3 mole) and sodium carbonate (20 grams) are charged into a glass reaction flask equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated to about 150°C for a period of about 8 hours. After this time the mixture is filtered and the filtrate is distilled to yield the desired product the dimethyl acetal of 2-(2-methyl-5-methoxymethylanilino)acetaldehyde.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. filtrationAfter this time the mixture is filtered
  4. distillationthe filtrate is distilled

Sources & evidence

ORD record
ord-caff47bc2731407e860bb8181d00453d
Source dataset
uspto-grants-1976_06
Patent number
US03966811

Reaction notes

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