HCID 21526869, compound → HCID 21526864, compound

Participants

Reaction Steps

A solution of 8,9-dihydro-3-methoxy-5-methyl-5,8-methano-5H-benzocyclohepten-10-amine [1.0 g. of α,β-amine mixture (9:1)] in 100 ml. of ethanol is hydrogenated over 150 mg. of platinum oxide catalyst under 48 psi hydrogen pressure in a Parr apparatus. Uptake of hydrogen is complete in one-half hour. The catalyst is filtered and the filtrate is concentrated. Gas chromatography of the residue identified it as a 9:1 mixture of α/β 6,7,8,9-tetrahydro-3-methoxy-5-methyl-5,8-methano-5H-benzocycloheptene-10-amine.

Provenance & Evidence