HCID 21525942, compound → HCID 21525916, compound

HRID 1659070Notes

Reaction equation

HRID 1659070 reaction equation
[O:1]=[CH:2][CH2:3][CH:4]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])=[CH:10][CH:9]=1)[C:5]([OH:7])=[O:6].[H][H]>[Pt]=O.C(O)C>[OH:1][CH2:2][CH2:3][CH:4]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])=[CH:10][CH:9]=1)[C:5]([OH:7])=[O:6]

Participants

5

Reactant 2

HCID 21525942HCID 21525942, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21525916HCID 21525916, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

To a suspension of γ-keto-(2'-chloro-4-biphenylyl)butyric acid 8.64 g. (0.031 mole) in 300 ml. of 90% ethanol is added 1 ml. of 0.1M ferrous sulfate solution followed by 0.5 g. of platinum oxide catalyst. The mixture is shaken with hydrogen for 31/2 hours. The catalyst is filtered off. The filtrate is distilled under reduced pressure to yield γ-hydroxy(2'-chloro-4-biphenylyl)butyric acid.

Workup

  1. filtrationThe catalyst is filtered off
  2. distillationThe filtrate is distilled under reduced pressure

Sources & evidence

ORD record
ord-070b7dac3fe74711bdc22668802e4eb0
Source dataset
uspto-grants-1976_06
Patent number
US03966801

Reaction notes

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