Sodium thiocyanate → HCID 21526408, compound

HRID 1659086Notes

Reaction equation

HRID 1659086 reaction equation
[S-:1][C:2]#[N:3].[Na+].Cl[CH:6]([CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])=[CH:14][CH:13]=1)[C:7]([OH:9])=[O:8]>C(O)C>[S:1]([CH:6]([CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])=[CH:14][CH:13]=1)[C:7]([OH:9])=[O:8])[C:2]#[N:3]

Participants

4

Reactant 2

HCID 516871Sodium thiocyanateHCID 21525974HCID 21525974, compound

Product 1

HCID 21526408HCID 21526408, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 300 ml. of anhydrous ethanol and 0.15 moles of sodium thiocyanate is added 0.12 moles of α-chloro-γ-(2'-chloro-4-biphenylyl)butyric acid and stirred for 15 hours. The reaction mixture is filtered and washed with absolute ethanol. The filtrate is evaporated to dryness, the residue is dissolved in 250 ml. of ether and washed several times with water. The ether is then dried and evaporated to dryness to obtain α-thiocyanato-γ-(2'-chloro-4-biphenylyl)butyric acid.

Workup

  1. filtrationThe reaction mixture is filtered
  2. washwashed with absolute ethanol
  3. customThe filtrate is evaporated to dryness
  4. dissolutionthe residue is dissolved in 250 ml
  5. washof ether and washed several times with water
  6. dry with materialThe ether is then dried
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-a71f0b9f3b4c45e8b32a17f2e5bad13e
Source dataset
uspto-grants-1976_06
Patent number
US03966801

Reaction notes

Loading…