Ammonia → HCID 86733637, compound

Participants

Reaction Steps

A mixture of acetoacetic acid (3-benzyloxy-2-propyl) ester (23.8 g), o-trifluoromethylbenzaldehyde (8.7 g.) and concentrated ammonia (10.0 ml. of density 0.88) in ethanol (200 ml) was stirred under reflux for 24 hours and then poured into ice and water. The yellow oil which precipitated was separated and purified by column chromatography to give as a pale yellow oil 1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)pyridine-3,5-dicarboxylic acid bis(3-benzyloxy-2-propyl)ester (24.8 g).

Provenance & Evidence