HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 5-Chloro-1-methyl-3-phenyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-methyl-3-phenyl-1H-pyrazol-5-ol | HCID 2763504 | — |
| Product | 5-Chloro-1-methyl-3-phenyl-1H-pyrazole | HCID 12665792 | 96.8% |
Reaction Steps
2-Methyl-5-phenylpyrazol-3-one (7.9 g, 0.0429 mol) is added to phosphorus oxychloride (15.3 g). The mixture is stirred at 120°C to 135°C for 8 hours, then poured into ice water, made alkaline and extracted with methylene chloride. The solution is evaporated in vacuo at 90°C to yield 8.0 g (93.8%) of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03966954 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-de7a0f14238246509b70e21123730f73 |
| Source note | uspto-grants-1976_06 |