Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1659162Generated: October 31, 2026

(4-Methoxyphenyl)hydrazine → (5-Methoxy-2-methyl-3-indoleacetoxy)-benzyl acetate

https://huagongshe.com/reaction/1659162

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Methoxyphenyl)hydrazineHCID 77023—
Reactant2-Oxo-2-(phenylmethoxy)ethyl 4-oxopentanoateHCID 12658376—
Product(5-Methoxy-2-methyl-3-indoleacetoxy)-benzyl acetateHCID 70621341—

Reaction Steps

condensing 4-methoxyphenylhydrazine or its salts with benzyl levulinoyloxyacetate according to Fischer to form (5-methoxy-2-methyl-3-indoleacetoxy)-benzyl acetate, subsequently acylating the alkali salt thereof with p-chlorobenzoyl chloride to form [1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indole-acetoxy]-benzyl acetate and then catalytically dehydrogenating the benzyl group (see reaction scheme A),

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03966956
Source datasetuspto-grants-1976_06
ORD IDord-b19030aa7b954764855971572f646c68
Source noteuspto-grants-1976_06