Potassium Iodide → HCID 21516772, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 4'-chloro-5'-methyl-6'-hydroxyspiro(cyclopentane-1,2'-indan)-1' ,3'-dione (9.3 g., 0.035 mole), chloroacetonitrile (2.83 g., 0.0375 mole), potassium carbonate (5.2 g., 0.0375 mole) and potassium iodide (6.2 g., 0.0375 mole) in dimethylformamide (100 ml.) is heated at 65°C. for 21/2 hours, cooled, then poured into water (1.5 1.) affording 10.7 g. of [1' ,3'-dioxo-4'-chloro-5'-methylspiro(cyclopentane-1,2'-indan)-6'-yloxylacetonitrile which melts at 137°-9°C. after recrystallization from ethanol-water.

Provenance & Evidence