Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 131710376, compound

HRID 1659198Notes

Reaction equation

HRID 1659198 reaction equation
[F:1][C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][C@H:10]2[C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH3:25])[CH:17]=2)=O)=[CH:4][CH:3]=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[F:1][C:2]1[CH:27]=[CH:26][C:5]([C:6]2[C:21]3[CH:20]=[C:19]([O:22][CH3:23])[C:18]([O:24][CH3:25])=[CH:17][C:16]=3[C@H:10]3[C@H:9]([CH2:14][CH2:13][N:12]([CH3:15])[CH2:11]3)[N:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 68140022HCID 68140022, compound

Product 1

HCID 131710376HCID 131710376, compound

Procedure

cis-4-(4-Fluorobenzoylamino)-3-(3,4-dimethoxyphenyl)-1-methylpiperidine is cyclized in analogy to the process described in Example 8. The dihydrochloride of the title compound has a M.P. of 250°-255° (from ethanol).

Sources & evidence

ORD record
ord-9b1dcf4bac4a417797f31db7297248a6
Source dataset
uspto-grants-1976_06
Patent number
US03966938

Reaction notes

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