Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 86733646, compound

HRID 1659199Notes

Reaction equation

HRID 1659199 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C@H:11]2[C@@H:16]([NH:17][C:18](=O)[C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=3)[CH2:15][CH2:14][N:13]([CH3:29])[CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[CH3:10][O:9][C:8]1[C:3]([O:2][CH3:1])=[CH:4][C:5]2[C@H:11]3[C@H:16]([CH2:15][CH2:14][N:13]([CH3:29])[CH2:12]3)[N:17]=[C:18]([C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=3)[C:6]=2[CH:7]=1

Participants

3

Reactant 2

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 68140932HCID 68140932, compound

Product 1

HCID 86733646HCID 86733646, compound

Procedure

cis-3-(3,4-Dimethoxypheny)-1-methyl-4-(4-nitrobenzoylamino)-piperidine [M.P. 167°, see Example 4 a)] is cyclized in analogy to the process described in Example 8. The dihydrochloride of the title compound has a M.P. of 225°-230° (from ethanol).

Sources & evidence

ORD record
ord-4e2df65faa704d46a50e67bfb3835b76
Source dataset
uspto-grants-1976_06
Patent number
US03966938

Reaction notes

Loading…