p-Anisoyl chloride → 4-Methoxy-N-{2-[2-(1-methylpiperidin-2-yl)propyl]phenyl}benzamide

Participants

Reaction Steps

Reaction of 2-[2-(2-aminophenyl)-1-methylethyl]-1-methylpiperidine with anisoyl chloride, according to the procedure of Example 25, provides 4-methoxy-2'-[2-methyl-2-(1-methyl-2-piperidyl)ethyl]benzanilide as a 72:28 mixture of diastereoisomers (according to nmr), m.p. 125.5°-136.5° C. (corr.).

Provenance & Evidence