2,4-Dichlorophenyl isocyanate → HCID 54432066, compound

HRID 1659287Notes

Reaction equation

HRID 1659287 reaction equation
[CH2:1]([O:3][C:4](=[NH:10])[NH:5][C:6]([O:8][CH3:9])=[O:7])[CH3:2].[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=1[N:19]=[C:20]=[O:21]>C1C=CC=CC=1>[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=1[NH:19][C:20]([NH:10][C:4](=[N:5][C:6]([O:8][CH3:9])=[O:7])[O:3][CH2:1][CH3:2])=[O:21]

Participants

4

Reactant 2

HCID 757892,4-Dichlorophenyl isocyanateHCID 140326695HCID 140326695, compound

Product 1

HCID 54432066HCID 54432066, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2 g of 2-ethyl-1-methoxycarbonylisourea [prepared as described in Japanese Patent Provisional Publication No. 49-25133 (1974)] and 1.88 g of 2,4-dichlorophenyl isocyanate were dissolved in 100 ml of benzene and the mixture was refluxed for 1 hour. The benzene was then removed by evaporation under reduced pressure and the residue was recrystallized from hexane, giving 2.7 g (yield 81%) of the desired compound as white needles melting at 92°-93° C.

Workup

  1. temperaturethe mixture was refluxed for 1 hour
  2. customThe benzene was then removed by evaporation under reduced pressure
  3. customthe residue was recrystallized from hexane

Sources & evidence

ORD record
ord-c14bb180100c4990858af660dfc0ee2d
Source dataset
uspto-grants-1981_12
Patent number
US04303440

Reaction notes

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