HCID 12764254, compound → Dicyclohexylamine

HRID 1659306Notes

Reaction equation

HRID 1659306 reaction equation
CO[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:12](=O)[C:13]([CH3:15])=C)C(C(O)=O)C2.[C:20](SCC(C)C(N1C2C(=CC(Cl)=CC=2)CC1C(O)=O)=O)(=O)[C:21]1C=CC=C[CH:22]=1>>[CH:12]1([NH:8][CH:9]2[CH2:10][CH2:11][CH2:3][CH2:4][CH2:5]2)[CH2:13][CH2:15][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 12764254HCID 12764254, compoundHCID 20456433HCID 20456433, compound

Product 1

HCID 7582Dicyclohexylamine

Procedure

By substituting 5-chloro-2,3-dihydro-1-(2-methyl-1-oxo-2-propenyl)-1H-indole-2-carboxylic acid from Example 34 for 2,3-dihydro-5-methoxy-1-(2-methyl-1-oxo-2-propenyl)-1H-indole-2-carboxylic acid in the procedure of Example 25, 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]-5-chloro-2,3-dihydro-1H-indole-2-carboxylic acid, dicyclohexylamine was obtained. The latter salt was then treated with 5% aqueous potassium hydrogen sulfate as in Example 15 to give the titled compound.

Sources & evidence

ORD record
ord-c6d197e24eff410e80490643d08b86f8
Source dataset
uspto-grants-1981_12
Patent number
US04303583

Reaction notes

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