4-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene → HCID 53633606, compound

HRID 1659313Notes

Reaction equation

HRID 1659313 reaction equation
[CH2:1]([O:3][C:4](=O)[CH2:5][N:6]([CH3:8])[CH3:7])[CH3:2].Br[C:11]1[CH:12]=[CH:13][C:14]([Cl:21])=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=1>>[CH3:7][N:6]([CH2:5][CH:4]1[CH2:14][CH:13]([C:11]2[CH:12]=[CH:13][C:14]([Cl:21])=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=2)[C:12]2[C:1](=[CH:2][CH:15]=[CH:16][CH:11]=2)[O:3]1)[CH3:8]

Participants

3

Reactant 2

HCID 679594-Bromo-2-chloro-alpha,alpha,alpha-trifluorotolueneHCID 118412Glycine, N,N-dimethyl-, ethyl ester

Product 1

HCID 53633606HCID 53633606, compound

Procedure

The process of example 4 was repeated using N,N-dimethylglycine ethyl ester in place of N,N-dimethylalanine ethyl ester in part (a), and using 5-bromo-2-chlorobenzotrifluoride in place of 4-bromochlorobenzene in part (c) to yield the title compound which was isolated as the hydrochloride salt.

Sources & evidence

ORD record
ord-bf9236b005234277a2dcaf82152b01e7
Source dataset
uspto-grants-1981_12
Patent number
US04303656

Reaction notes

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