反应详情

To a stirred solution of 2-(N-benzyl-N-methylaminomethyl)chroman-4-one (4.9 g) in dry diethyl ether (200 ml) under an atmosphere of dry nitrogen at room temperature, was added a two molar excess of phenyllithium solution and the resulting mixture was boiled for 2 hours before being poured onto ice/dilute HCl. The solution was basified and extracted with ether to give the crude 2-(N-benzyl-N-methylaminomethyl)-4-phenyl-4-hydroxychroman as an orange oil.

1. additionbefore being poured onto ice/dilute HCl
2. extractionextracted with ether