HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 5-(o-Aminophenyl)-4-nitropyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4-Chloro-3-nitroquinoline | HCID 11275808 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(o-Aminophenyl)-4-nitropyrazole | HCID 20560260 | 83% |
Reaction Steps
A mixture of 20.8 g (0.1 mole) of 4-chloro-3-nitroquinoline, 40 ml of benzene and 40 ml of hydrazine hydrate is refluxed for 2 hours, then cooled. The separated phase containing hydrazine hydrate is diluted with 150 ml of water. Yellow-white crystals separate. Thus, 16.8 g (83%) of 5-(o-aminophenyl)-4-nitropyrazole are obtained. M.p.: 175°-176° C. (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04303660 |
| Source dataset | uspto-grants-1981_12 |
| ORD ID | ord-599f851ef7c24e7fa1bd7049325a8a63 |
| Source note | uspto-grants-1981_12 |