Acetic Anhydride → HCID 13175646, compound

HRID 1659327Notes

Reaction equation

HRID 1659327 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][N:11]=[CH:10][C:9]=1[N+:13]([O-:15])=[O:14].[C:16](OC(=O)C)(=O)[CH3:17]>O>[N+:13]([C:9]1[CH:10]=[N:11][N:12]2[C:8]=1[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:1]=[C:16]2[CH3:17])([O-:15])=[O:14]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 205602605-(o-Aminophenyl)-4-nitropyrazole

Product 1

HCID 13175646HCID 13175646, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

20.4 g (0.1 mole) of 5-(o-aminophenyl)-4-nitropyrazole are heated with 100 ml of acetic anhydride for 2 hours under reflux. The solution obtained is poured into water, the precipitate that solidifies is filtered off, washed with water, dried, then boiled in a ten times' quantity of xylene for 5 hours. Thus, 11.4 g (50%) of 1-nitro-5-methylpyrazolo[1,5-c]quinazoline are obtained. M.p.: 178°-179° C.

Workup

  1. temperatureunder reflux
  2. customThe solution obtained
  3. filtrationthe precipitate that solidifies is filtered off
  4. washwashed with water
  5. customdried
  6. customfor 5 hours

Sources & evidence

ORD record
ord-55f501ee2a2542378c7e0b9e3cbebcd8
Source dataset
uspto-grants-1981_12
Patent number
US04303660

Reaction notes

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