HCID 13175644, compound → HCID 13175647, compound

HRID 1659328Notes

Reaction equation

HRID 1659328 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]2[C:16]=1[C:15]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:9]=[CH:8]2)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]2[C:16]=1[C:15]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:9]=[CH:8]2

Participants

5

Reactant 2

HCID 13175644HCID 13175644, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13175647HCID 13175647, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

21.4 g (0.1 mole) of 1-nitropyrazolo[1,5-c]quinazoline are treated with hydrogen in ethanol and in the presence of palladium/carbon at room temperature and atmospheric pressure. When the hydrogen consumption ceases, the solution is filtered and evaporated. 14.7 g (80%) of 1-aminopyrazolo[1,5-c]quinazoline are obtained. M.p.: 168°-170° C.

Workup

  1. customWhen the hydrogen consumption ceases
  2. filtrationthe solution is filtered
  3. customevaporated

Sources & evidence

ORD record
ord-4b8f3eb5355c457e93be660e11305905
Source dataset
uspto-grants-1981_12
Patent number
US04303660

Reaction notes

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